CD4 and lymphopenia: Case descriptions reported of lymphopenia in MIS-C patients, and the investigation of the immunological behavior of MIS-C patients has shown, in ~75% of patients, the polyclonal expansion of CD4+ and CD8+ T cells bearing the Vβ21.3 segment and TCR V11-2 skewing in association with HLA A*02, B*35 and C*04 [13].