Hypoalbuminemia (a serum albumin <3.0 g/dL in term neonates an  <2.5 g/dL in preterm newborns) is a risk factor for bilirubin neurotoxicity, as low serum albumin levels may enhance the risk of bilirubin encephalopathy by lowering the bilirubin–albumin binding capacity [36,37]. This evidence concerns the gene ALB and Hypoalbuminemia.