The tyrosinase pathway, which starts with microphthalmia-associated transcription factor (MITF), is also connected to the PI3K/Akt pathway in vitiligo, as MITF is a regulator of melanocyte differentiation, pigmentation, proliferation, and survival, and is responsible for mediating tyrosinase as well as tyrosine-related protein 1 (TRP1) and TRP2. The gene discussed is TYR; the disease is vitiligo.