In psoriasis, uncontrolled keratinocyte proliferation is associated with activation of the mTOR pathway and involves different Th-1, Th-17, and Th-22 immune cells, and their effector cytokines (e.g., IL-1β, IL-6, IL-17A, TNF-α) that act on keratinocytes [100]. This evidence concerns the gene TNF and psoriasis.