RAC1 and psoriasis: More important to the kit, downstream effectors of mTORC2 such as the epidermal Rho small GTPases (Ras-related C3 botulinum toxin substrate 1–3 (Rac1–3), particularly hyperactivation of epidermal RAC1 has been shown to promote psoriasiform inflammation that closely resembles human psoriasis [136].