Insulin-like growth factor binding protein-5 (IGFBP-5) has also been identified in cultured dermal fibroblasts derived from SSc patients, which was established as a trigger of fibrotic phenotype through the induction of ECM assembly, the transformation of fibroblasts to myofibroblasts, as well as the infiltration of inflammatory mononuclear cells to the sclerotic skin lesion [165]. The gene discussed is IGFBP5; the disease is systemic sclerosis.