Mitra et al. reported that IL-22-induced proliferation of NHEK and fibroblast-like synoviacytes (FLS) is dependent on the PI3K-Akt-mTOR signaling pathway, suggesting the possibility of developing novel treatments targeting this pathway in chronic immune-mediated diseases such as AD, psoriasis, and rheumatoid arthritis. This evidence concerns the gene PIK3CD and Alzheimer disease.