TYR and vitiligo: The most well-studied genes are the tyrosinase gene (TYR; limiting step for melanocyte biosynthesis and also found to be a major autoantigen in generalized vitiligo), NALP1 (found on chromosome 17p13 and encoding the NACHT leucine-rich protein 1), and XBP1P1 gene (x-box binding protein 1; commonly associated with vitiligo [301].