Luteolin can inhibit or modulate pathways/molecules such as NF-κB, MAPK, PI3K as well as pro-inflammatory mediators, hence it has been used in the management of chronic inflammatory and metabolic diseases such as contact dermatitis, psoriasis, cancer, diabetes, neurocognitive and neurodegenerative disease [358,359,360]. The gene discussed is NFKB1; the disease is psoriasis.