KEGG pathway analysis showed that upregulated genes were mainly enriched in five signaling pathways, namely hypertrophic cardiomyopathy (Slc8a1, Pde1c, Cacna1c), endocytosis (Igf1r, Cyth1, Acap2, Met, Psd3), the Ras signaling pathway (Igf1r, Pak3, Met, Rasa2), the cGMP-PKG signaling pathway (Slc8a1, Cacna1c, Trpc6), and the calcium ion signaling pathway (Slc8a1, Cacna1c, Ttn). Here, PAK3 is linked to hypertrophic cardiomyopathy.