All the events that follow virus entry lead to an imbalanced innate and adaptive host response, defined by low levels of type I and III interferons (IFNs), elevated chemokines, and high expression of interleukin (IL)-6, inducing a reduction of innate antiviral defenses [53], and generating the so-called “cytokine storm”, one of the main mechanisms for ARDS, which is the main cause of death in COVID-19 patients. The gene discussed is IL6; the disease is COVID-19.