CD209 and viral infectious disease: The DC-SIGN/CD209 (dendritic-cell-specific intercellular adhesion molecule-3-grabbing nonintegrin) and the other CLRs can regulate immune responses via Toll-like receptors (TLRs), and TLR2 cooperates with the monocyte surface molecule CD14 in response to viral infection, leading to the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), inducing the production of inflammatory cytokines.