Additionally, hepatocytes produce growth factors such as insulin-like growth factor-1 (IGF-1), hepatocyte growth factor-like protein (HGFL), and heregulin, which can enhance tumor growth, motility, and invasion [104,105], while also triggering angiogenesis by inducing basic fibroblast growth factor (bFGF) production [9,106]. The gene discussed is FGF2; the disease is neoplasm.