Interactions of tumor cells to hepatocyte-derived ECM may upregulate gene expression that promotes survival, motility, and proliferation of cancer cells, such as heparin-binding epidermal growth factor (HB-EGF) and the colon stem cell marker leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) [102]. The gene discussed is HBEGF; the disease is neoplasm.