Cardioprotection (significantly reduced infarct size, decreased troponin T levels and improved cardiac function in murine model myocardial I/R) [57]Anti-apoptotic effects via the activation of RISK pathwayReduced TRPV4-related mechanosensitive Ca2+ signaling in DCM-hiPSC-CMsPrevents entry of divalent cation in response to myocyte-stretching- and hypoosmotic-stress-induced cardiomyocyte death and ischemia–reperfusion-induced cardiac damageSignificantly reduced diabetes-induced cardiac fibrosisInhibition of the PE-induced contraction in pulmonary artery smooth muscle cells. Here, TRPV4 is linked to familial dilated cardiomyopathy.