In line with these results, several in vitro investigations of rat or human CFs have shown a rapid but sustained increase in Ca2+ influx in response to TRPV4 agonist perfusion (4αPDD [116] or GSK1016790A [82]), which promotes the fibroblasts’ differentiation into myofibroblasts. Here, TRPV4 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.