MAPT and Alzheimer disease: AD is associated with the accumulation of amyloid-beta (Aβ) and phosphorylated-tau (p-Tau), in addition to hormonal imbalance, synaptic damage, mitochondrial abnormalities, microRNA deregulation, and increased glia and astrocytes [3,4,5,6,7,8,9,10,11,12,13,14,15].