Therefore, to further explore the possible role of SGK1 in regulating nerve function, this study uses SGK1 inhibitors to inhibit the expression of SGK1 in rat adrenal pheochromocytoma-derived PC12 cells, which is a commonly used in vitro research platform for neuroscience research. The gene discussed is SGK1; the disease is hereditary pheochromocytoma-paraganglioma.