ANPEP and cardiovascular disorder: We further observed a significant correlation between Sgk1 and markers of coronary artery including Mmp9, Ccl2, and Anpep (Figure 9), demonstrating that the expression level of SGK1 is positively correlated to neuromodulation in cardiovascular disease, indicating that SGK1 may have a contributing role in cardiovascular regulation of PC12, although further studies will be necessary to confirm the underlying mechanisms.