Li et al. identified an EC subtype with higher IGFBP7 expression in psoriasis patient skin lesions, which promoted psoriasis via destruction of the endothelial glycocalyx, and antibody-mediated blockade of IGFBP7, which attenuated T-cell adhesion on EC layers in a mouse psoriasis model [145]. Here, IGFBP7 is linked to psoriasis.