HNRNPH2 and amyotrophic lateral sclerosis: Moreover, one study showed more directly relevant evidence for the association between hnRNP H and FTLD/ALS, in which approximately 50% of the investigated sporadic FTLD and ALS cases presented elevated levels of insoluble hnRNP H in the brain, as well as splicing abnormalities in a spectrum of hnRNP H downstream regulatory targets [54].