FAT1 expression is lower in both esophageal squamous cell carcinoma and cervical cancer; notably, FAT1 knockdown promotes migration and invasion in esophageal squamous cell carcinoma cell lines and of HeLa and C33A cells, while FAT1 overexpression abrogates these cellular activities [14,36,37]. The gene discussed is FAT1; the disease is esophageal squamous cell carcinoma.