Khan et al. [63] found that Ezrin skews the differentiation of THP-1 macrophages toward the pro-tumorigenic M2 phenotype, contributing to factors that stimulate tumor cell migration, invasion, and clonogenic growth, as well as the expression of mRNAs encoding vascular endothelial growth factor (VEGF)-A and matrix metalloproteinase (MMP)-9. This evidence concerns the gene MMP9 and neoplasm.