EBP50 can have either antitumor or pro-tumor functions, dictated by its expression or subcellular localization in either the plasma membrane or nucleus, and this dual function encompasses its regulation of several major signaling pathways, including receptor tyrosine kinases PDGFR and EGFR, the PI3K/PTEN/AKT pathway, and the Wnt/β-catenin pathway [169]. This evidence concerns the gene AKT1 and neoplasm.