Preclinical studies in MC38 expressing CEA colon and 4T1 TNB cancer models examined the effects of N803 in combination with the class I histone deacetylase (HDAC) inhibitor entinostat plus adenovirus-based vaccines targeting the pan-cancer carcinoembryonic antigen (Ad-CEA) or Twist1 (Ad-Twist1), a metastasis-associated transcription factor [56]. The gene discussed is CEACAM5; the disease is cancer.