CD274 and neoplasm: The stimulatory effects mediated by N803 have also been observed in human xenograft models of oral cavity squamous carcinomas, where the addition of N803 to the combination of a PD-1-targeting mAb plus adoptive transfer of an irradiated human NK cell line harboring a PD-L1-specific chimeric antigen receptor (CAR) elicited synergistic tumor control [55].