Similarly, in experimentally induced chronic kidney failure [114], the administration of renalase ameliorates kidney and cardiac phenotypes observed as significantly reduced proteinuria, glomerular hypertrophy, renal interstitial fibrosis, hypertension, cardiomyocytes hypertrophy, cardiac interstitial fibrosis, and the prevention of cardiac remodeling through the inhibition of pro-fibrotic gene expression and ERK1/2 phosphorylation. The gene discussed is RNLS; the disease is Interstitial cardiac fibrosis.