The initial hypothesis that linked renalase to the oxidative metabolism of NAD(P)H and raised the awareness that renalase may be a tool for cardiomyocyte energy metabolism preservation [44,53,54,55] was established upon evidence that renalase deficiency results in significant cardiomyocyte necrosis and mild ventricular hypertrophy [59]. Here, RNLS is linked to cardiac hypertrophy.