This response ultimately results in the apoptosis of tumor and endothelial cells via a number of different mechanisms including the activation of CD36-mediated apoptotic signaling, blocking the CD47 “don’t eat me” immune checkpoint, promoting M2-to-M1 TAM repolarization, as well as increasing the rates of the activation and infiltration of cytotoxic lymphocytes (CTLs) [93]. Here, CD47 is linked to neoplasm.