Further to its role in recruitment of neutrophils, IL-17A signals through IL-17RA on Kupffer cells to promote production of TGF-β1 (transforming growth factor β1) [150], which, in turn, promotes hepatic stellate cell (HSC) activation and extracellular matrix secretion, contributing to NAFLD progression [151]. Here, IL17RA is linked to metabolic dysfunction-associated steatotic liver disease.