On the other hand, a delay in the production of IFNs (3–4 days post-infection) results in ineffective innate and acquired immune responses [38], despite persistent IL-6 and TNF-α release by several cells, infiltrating monocytes, inflammatory reactions, and a dysfunctional response amplified by macrophages [39], which may lead to the critical form of COVID-19. This evidence concerns the gene TNF and COVID-19.