While this difference was not significant (Supplementary Figure S3A), the analysis of the individual normalized gene expression levels of astrocyte function-related genes revealed that Osgin1 (Supplementary Figure S3B) and Cd109 (Supplementary Figure S3C) were downregulated in Trem2−/− AD-tau versus WT AD-tau mice. The gene discussed is TREM2; the disease is Alzheimer disease.