MAPT and Alzheimer disease: Our partial transcriptomic analysis did not reveal any increase in known DAM markers [46] in WT mice injected with AD-tau in comparison with the levels in Trem2−/− mice injected with AD-tau (Supplementary File S1), suggesting that the effect of TREM2 ablation on tau propagation in this model is not due to an effect on the ability of microglia to adopt a DAM phenotype.