IL1B and intervertebral disk degenerative disorder: The plausible reason for these discrepancies could be the genetic heterogeneity in different populations [38], or it could be due to the inhibition of transcription factors by the IL-1β-511 CC genotype to bind promoter regions leading to suppression of gene expression, unlike the IL-1β-511 TT genotype, which positively ameliorates gene expression and exacerbates disc degeneration [24].