In this study, we aimed to assess whether LRRK2-I1371V brings about cell-intrinsic alterations to the astroglial biology involving glutamate uptake and metabolism and Nrf2-mediated glutathione machinery and ATP generation using astrocytes derived from LRRK2-I1371V PD-patient iPSCs and LRRK2-I1371V-overexpressed U87 cells. Here, NFE2L2 is linked to Parkinson disease.