The present study established that astrocytes derived from the iPSCs of PD patients carrying the LRRK2-I1371V mutation had a similar yield as those derived from HCs but distinctly displayed a cell-intrinsic impairment of the Nrf2-mediated antioxidant system and glutamate uptake and metabolism, both core functions of astrocytes. Here, NFE2L2 is linked to Parkinson disease.