To gain a first insight into whether hypoxia is able to influence the expression of DUBs involved in the overall survival of colon cancer (Supplementary Figure S1) we examined the mRNA and protein expression of USP7, USP10, USP33, USP40, USP45, USP46, YOD1, and JOSD1 in HEK293 cells exposed to normoxia (16% O2) and hypoxia (1% O2). Here, USP46 is linked to colonic neoplasm.