Moreover, dysregulation of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a transcriptional coactivator involved in the regulation of mitochondrial biogenesis and function [100], has been shown to contribute to the development of AKI by impairing mitochondrial function in immune cells [101,102,103]. Here, PPARGC1A is linked to acute kidney injury.