BIN1 and Charcot-Marie-Tooth disease: Interestingly, naturally occurring mutations have been reported in amphipathic helix-containing membrane fission-inducing proteins and are the basis of human diseases [71] such as centronuclear myopathy (amphiphysin 2), Charcot-Marie-Tooth disease (GDAP1), Parkinson’s disease (α-synuclein).