Apart from having pro-proliferative activity, miR-21 also promotes tumor invasion and migration [31], as it induces tumor invasion by targeting regulators of matrix metalloproteinase, such as RECK (reversion inducing cysteine-rich protein with Kazal motifs) and TIMP3 (tissue inhibitor of metalloproteinase) [24,30]. Here, TIMP3 is linked to neoplasm.