Moreover, Sirtuin 1, another regulator of BA homeostasis, appears to play a crucial role in modulating the regenerative response of the liver through post-transcriptional modifications, including acetylation of FXR and neighboring histones, which potentially contribute to CCA onset by disrupting the homeostasis of BAs via persistent FXE deacetylation. This evidence concerns the gene SIRT1 and cholangiocarcinoma.