CDX2 and lung cancer: As a proof of this concept, the injection of murine colon adenocarcinoma-derived EVs into the blood stream of immunodeficient NOD-SCID mice resulted in the formation of adenocarcinomas in the lung, with characteristics of both poorly differentiated colon cancer (positive for CK20, CDX2 and AE1/AE3) and lung cancer (positive for Thyroid transcription factor 1 (TTF1) and Napsin) (Figure 3), confirming that EVs derived from a given cancer type target different cell populations at the metastatic niche and induce their transformation [183].