These results corroborate our prior work in global p58IPK KO mice, which demonstrate that a lack of p58IPK results in increased apoptosis and cell death of RGCs in multiple physiological and pathological conditions including aging, N-methyl-D-aspartic acid (NMDA)-induced neurotoxicity, retinal ischemia, increased IOP, and ER stress [14,15]. The gene discussed is DNAJC3; the disease is retinal ischemia.