Significant differences were found in age, severe COVID-19 frequency, Brixia score, white blood cell count, lymphocyte count, CRP, procalcitonin, glucose, urea, creatinine, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, creatine kinase-MB, lactate dehydrogenase, proBNP, troponin, albumin, and D-dimer. This evidence concerns the gene NPPB and COVID-19.