FLCN and Birt-Hogg-Dube syndrome: The major diagnostic criteria for BHD, suggested by Menko et al. in 2009, are: (1) skin manifestations (fibrofolliculomas or trichodiscomas) and (2) FLCN mutation; minor criteria (1) multiple lung cysts, (2) renal cancer, and (3) a first-degree relative with BHD [1].