Consistent with the first studies about HBME1, stating that “HBME1 highlights cellular glycoconjugates changes related to malignant transformation” [34], we hypothesize that an important role could be played by anomalous Tg glycosylation, which leads to the formation of the HBME1 target antigen, determining the immunoreactivity for HBME1 of the colloidal substance and simultaneously acting as trigger for focal lymphocytic thyroiditis. Here, TG is linked to Hashimoto thyroiditis.