Regarding the rs10485505 genotype of circ-ITCH polymorphisms, our results proved that the carriers of the T allele frequently have poor prognosis compared to carriers of the CC genotype, as carriers of the CT and TT genotypes had significant positive LN metastasis, advanced tumour stage, and poor histological grade (p < 0.001) (Table 4). Here, ITCH is linked to neoplasm.