Correlation between circ-ITCH mRNA expression and β-catenin protein level calculated on 62 breast cancer patients showed that there was a statistically significant negative correlation between circ-ITCH mRNA expression and β-catenin protein level in breast cancer patients (r − 0.3) (p-value < 0.05 *) (Figure 4). This evidence concerns the gene ITCH and breast carcinoma.