The relative expression levels of circ-ITCH were remarkably decreased on the contrary, β-catenin serum levels showed a significant markedly increase in the BC samples of patients carrying the A allele of rs4911154 and T allele of rs10485505 According to Kaplan–Meier survival analysis, the expression of circ-ITCH is associated with the prognosis of breast cancer. The gene discussed is ITCH; the disease is breast cancer.