As an explanation for our findings and the potential role of rs10485505 and rs4911154 in circ-ITCH in increasing the risk of BC, Guo et al. found that because circ-ITCH may have an inhibitory effect on HCC, these SNPs in circ-ITHC were significantly associated with an increased risk of HCC [20]. The gene discussed is ITCH; the disease is hepatocellular carcinoma.