TP53 and neoplasm: Considering that the POLEmut class contains tumors with a high number of intra-tumor lymphocytes and aberrant p53 expression, the tumors with intra-tumoral TIL-high with aberrant p53 expression observed in this study might reflect tumors of the POLEmut class in the TCGA classification system; however, this association could not be proven due to the lack of mutation analysis.