The highest percentage of positive E-cadherin expression was found in the invasive front (98.18%) and in the tumor center (98.18%); it was much smaller (76.37%) in the budding sites (ECD-IF vs. ECD-BS, p < 0.05; ECD-TC vs. ECD-BS, p < 0.05) and the smallest (43.64%) in the regional lymph nodes (ECD-IF vs. ECD-LN, p < 0.05; ECD-TC vs. ECD-LN, p < 0.05) (Figure S1 in Supplementary Files). The gene discussed is CDH1; the disease is neoplasm.