CDH1 and neoplasm: Concerning the tumor center, the distribution of E-cadherin expression was the most interesting and progressively variable; 16.36% of CRCs presented weak membranous staining of E-cadherin (ECD-1), 29.09% presented moderate membranous staining (ECD-2), and 52.73% presented intense membranous staining (ECD-3) (Figure S1 in Supplementary Files).