CDH1 and metastatic malignant neoplasm in the lymph nodes: A recent meta-analysis including 9591 colorectal cancer patients seems to strongly support our findings, as it was found that low E-cadherin expression was significantly associated with the more advanced neoplastic disease: a shorter overall survival and disease-free survival, a higher risk of low differentiation, a high risk of distant metastasis, a high risk of vascular invasion, a higher risk of lymph node metastasis, a high risk of lymphatic invasion, and a high risk of deep infiltration [45].