Furthermore, E-cadherin expression in the tumor center was higher in CRCs with lower areas of poorly differentiated components (POR-1) than in those with higher ones (POR-2+3) (p = 0.005), and in the tumor center, it was higher in CRCs with lower poorly differentiated clusters (PDC-1) than in those with higher ones (PDC-2+3) (p = 0.008) (Figure 2). The gene discussed is CDH1; the disease is neoplasm.