Weak membranous expression of E-cadherin staining (ECD-1) was most commonly found in the invasive front (32.73%) and in the budding sites (32.73%), but a strong membranous pattern of staining (ECD-3) was most common in the tumor center (52.73%); it was much smaller in the regional lymph nodes (34.55%) and the smallest both in the budding sites (29.09%) and the invasive front (29.09%) (Figure S2 in Supplementary Files). Here, CDH1 is linked to neoplasm.