ADAM8 and cancer: To determine the potential role of Adam8 in the cell-signaling crosstalk between MSCs and cancer cells toward the induction of the myCAF phenotype with a concomitant increase in cancer stemness, we performed coculture studies in which human MSC cells were cultured with either MDA-MB-231 breast cancer cells or HepG2 liver cancer cells and the Adam8 antibody added at different time points to block Adam8 bioactivity.