Of note, dysregulated expression and function of LIN28A/B and the let-7 family has been characterized in other pediatric non-glioma brain tumors, including embryonal tumor with multilayered rosettes, atypical teratoid rhabdoid tumor, and medulloblastoma [45,46,47,48,49,50,51,52]. Here, LIN28A is linked to central nervous system cancer.