Another study found that let-7 family members function in a UUGU motif-dependent manner, as toll-like receptor 7 (TLR7) ligands to regulate tumor microglia: treatment with let-7b/e decreases growth of a murine glioma model by increasing microglial infiltration in a TLR7-dependent manner [56]. The gene discussed is TLR7; the disease is glioma.