It has been shown in pancreatic cancer that K-RAS can drive protein kinase C β (PKCβ) to phosphorylate LIN28B at serine 243 (S243), promoting translocation, which leads to decreased let-7i expression and increased expression of the let-7i target, TET3 (Figure 7, [141]). This evidence concerns the gene PRKCB and familial pancreatic carcinoma.