Let-7 also targets pre-B-cell leukemia homeobox 3 (PBX3) in glioma, a protein which mediates transforming growth factor β (TGF-β) signaling, driving the expression of genes that increase migration—N-cadherin (N-cad), zinc finger E-box-binding homeobox 1 (ZEB1), SNAI2, and CD44 [66]. The gene discussed is PBX3; the disease is central nervous system cancer.