LIN28A is an established regulator of cancer metabolism: LIN28A binds to the mRNAs of several glycolytic and insulin signaling genes to increase their translation, thereby increasing glycolysis and glucose uptake, as well as derepresses a let-7 target that inhibits pyruvate entry into the tricarboxylic acid cycle, thereby reenforcing aerobic glycolysis [81]. The gene discussed is LIN28A; the disease is cancer.