In this way, LIN28B promotes transformation and migration in colon cancer through LGR5, PROM1, and CDX2 mRNAs, promotes stemness and EMT in gastric cancer through NRP-1 mRNA, inhibits apoptosis in ovarian cancer through AKT2 mRNA, and promotes migration in neuroblastoma through MYCN-induced mRNAs [151,152,153,154,155]. The gene discussed is PROM1; the disease is colonic neoplasm.