Based on the importance of the 28 hub genes in BC and using stringent filter conditions such as the genes predicted to be diagnostically important by at least five ML methods and present in at least seven BC datasets, a novel nine-gene signature (COL10A, S100P, ADAMTS5, WISP1, COMP, CXCL10, LYVE1, COL11A1, and INHBA) was identified. Here, S100P is linked to breast cancer.