With more stringent conditions (DEGs > 5 ML and DEGs > 7 dataset) and based on their role in tumorigenesis, a novel diagnostic nine-gene signature (COL10A, S100P, ADAMTS5, WISP1, COMP, CXCL10, LYVE1, COL11A1, and INHBA) was identified for BC. The gene discussed is COMP; the disease is breast cancer.