CYP1A2 and hereditary hemochromatosis: As another example, UGT1A1*28, UGT1A1*60, and cytochrome P450 1A2 (CYP1A2) rs762551 were associated with a pazopanib-related increase in bilirubin, while SNPs in hereditary hemochromatosis gene (HFE) were associated with increased levels of ALT.