High levels of TILs generally correspond to better outcomes in OSCC, but this is dependent on the balance of cells with anti-tumor activity (effector T or Teff cells) versus those with immunosuppressive activity (regulatory T or Treg cells) in the TIL population [76,78].Teffs are related to high levels of cytotoxic CD8+, which produces IFN-Υ [76]. This evidence concerns the gene CD8A and neoplasm.