We identify an altered expression of CD274 and CD206 in classical, intermediate, and non-classical monocytes between tumor and non-tumor samples, as well as between desmoplastic and non-desmoplastic growth patterns, indicating that patients with a desmoplastic growth pattern are more likely to have a better prognosis and benefit from anti-PD-L1 immunotherapy. Here, MRC1 is linked to neoplasm.