For example, in a case of MDS (sample 6), OGM detected a heterozygous interstitial deletion on chr 4 [4q24q25(103311803_107478954)x1], which included the TET2 gene, while the sequencing data detected a pathogenic frameshift variant (TET2p.S1132Lfs*6, Tier 2C classification) on the other allele (Figure 5a). The gene discussed is TET2; the disease is myelodysplastic syndrome.