In SPOCK1-depleted ccRCC cell line CAKI-1, MMP-2, -3 and -9 were found downregulated, while only MMP-2 was downregulated in SPOCK1-depleted 786-O ccRCC cell line, thus suggesting MMP-2 as a general target in ccRCC cells. Here, SPOCK1 is linked to nonpapillary renal cell carcinoma.