The results showed that while the low-fat diet group experienced a worsening of colonic inflammation and a higher incidence of CRC, the high-fat diet reduced inflammatory cytokines such as IL-1β, IFNγ and IL-12 and increased protective cytokines (IL-2, IL-10) in both colitis only and colitis associated CRC. The gene discussed is IL1B; the disease is colorectal carcinoma.