Hereditary colonic polyposis syndromes, such as familial adenomatous polyposis, which result from a germline alteration in the adenomatous polyposis coli (APC) gene and MUTYH-associated polyposis, are caused by biallelic pathogenic variants and predispose individuals to increased risk of CRC, although these are less common than Lynch syndrome [78,79,80,81]. The gene discussed is APC; the disease is colorectal carcinoma.