Prognostic biomarkers that have been described to influence the prognosis for other carcinomas of the head and neck often include tumor suppressor genes such as the p53 gene [32,33], oncogenes such as the EGFR gene and upregulated proteins commonly found in carcinomas, such as carbonic anhydrase expression [34], miR-21 expression [35] and programmed death ligand-1 expression [36,37]. The gene discussed is TP53; the disease is carcinoma.