As the combined treatment with TGF-β1 and hypoxia appeared to induce actomyosin reorganization to prepare cancer cells for migration—any peripheral EOC could potentially act as leader cell for collective cell migration but may need additional directional cues in the tumor microenvironment, such as platelet-derived growth factor (PDGF), for such changes to occur [58]. The gene discussed is TGFB1; the disease is neoplasm.