Figure 4A suggests that MBD3 participates in a variety of biological processes in tumors, such as EMT, Hypoxia, and invasion. In colon cancer, MBD3 was positively correlated with Differentiation, Angiogenesis, Inflammation, Hypoxia, and Apoptosis, and negatively correlated with CellCycle and DNAdamage (Figure 4B). This evidence concerns the gene MBD3 and malignant colon neoplasm.