MBD3 and malignant colon neoplasm: We explored the effect of MBD3 on colon cancer prognosis using KM curves, which showed that low MBD3 expression resulted in a better prognosis, while high MBD3 expression resulted in a poor prognosis (Figure 2A), and risk factor plots further confirmed that MBD3 high expression was associated with poor prognosis (Figure 2B).