MBD3 and DEGs were mainly enriched in: Systemic lupus erythematosus, Alcoholism, Neutrophil extracellular trap formation, Olfactory transduction and Taste transduction (Figure 4G), GSEA functional enrichment suggests that they are involved in Transport of Small Molecules and Hemostasis (Figure 4H). Here, MBD3 is linked to alcohol dependence.