IRF8 and neoplasm: Furthermore, a number of interferon (IFN) response genes (BST2, CD74, HLA-DMA, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1, and IRF8) were upregulated in C10 compared to the other clusters, whereas genes associated with tumor suppression and apoptosis (TFF1 and TFF2) were downregulated (Figure 5D).