This includes the percentage of BM blasts, the FAB subtype of CMML (WBC > 13 × 109/L), the need for transfusion support, and the presence of genetic markers (ASXL1, RUNX1, NRAS, SETBP1, and cytogenetic abnormalities) as risk factors. The gene discussed is ASXL1; the disease is chronic myelomonocytic leukemia.