Adding a monoclonal antibody directed against CTLA4 to an anti-PD1 can bypass resistance to single agent immunotherapy; dual immune checkpoint blockade with Nivolumab/Ipilimumab has already been approved in previously untreated renal cell carcinoma and many other diseases, such as melanoma, NSCLC, and colorectal cancer. The gene discussed is CTLA4; the disease is melanoma.